Quantum theory can be completely stated in the complex projective space of a complex Hilbert space. The basic object from this perspective is the transition probability of a couple of rays (pure states). That is computed as a suitable distance on the said projective space which makes it complete as a metric space.
So, in principle, the zero vector does not play any explicit role as it does not determine an element of the projective space.
However, the above approach turns out to be mathematically cumbersome and awkward when performing explicit computations. In summary, it is practically convenient to work in the associated Hilbert space. This is practical on the one hand, and cause of difficult issues on the other hand, for instance when dealing with groups of symmetries and their unitary projective representations. The use of $SU(2)$ in place of $SO(3)$ to describe the representations of the physical rotations on states is an effect of that choice. In the projective space the relevant group is the physical one ($SO(3)$), but it is replaced by its universal covering $SU(2)$ when dealing in the Hilbert space.
Varadarajan’s book “The geometry of quantum theory” develops (also) these ideas.