Usual textbook quantum mechanics tells us that observable quantities are associated with Hermitian operators. However, there are many instances where we seek to measure parameters encoded in the quantum state that do not have an associated Hermitian observable. This is where quantum parameter estimation (QPE) theory enters. To my knowledge, there are essentially two types: frequentist and Bayesian quantum parameter estimation. The celebrated quantum Cramér-Rao bound is perhaps the most famous result in frequentist, asymptotic QPE.
In the context of a single copy of the system whose state contains some parameter I want to learn, clearly the iid (independent, identically distributed) paradigm drops. Further, it is clear that the process of: i) coupling the system to my probe, ii) letting them interact, iii) collect my probe, iv) measure my probe will inevitably "affect" the system, and therefore not only the parameter's assumed pre-value, but even its functional dependency on the state.
All this makes me wonder: is there a "quantum parameter estimation" framework that allows for these type of situations? My initial line of thought was: Assuming someone has prepared the state $\rho_\lambda$ in such a way that the parameter $\lambda$ has a true, fixed, real value (within some acceptable error, naturally (real numbers are not physical from an operational point of view), and even assuming that I know the functional encoding of the parameter, could I view the fact that upon the first probing I will inevitably change the state to something else as making the initially local estimation fuzzier? That is, is there a theory of quantum parameter estimation where limited resources (i.e. single copy and perhaps some restriction on the type of available POVM) are formalised as a "noisy" transition from local estimation to global estimation?