We know that measurements and interactions between particles and their environment conserve the net quantum information (the total between the system and the measurement device/environment) in the sense of von Neumann entropy, none is created or destroyed. Do we know much quantum information is contained in a typical macroscopic object, or how much the universe started off with?
I'm imagining a thought experiment where I start off with N fermions all initially in fully pure states, von Neumann entropy = 0. The particles can become entangled, emit photons etc but the net entropy of the system will not change. The system could separate itself back into an unentangled state, either if you wait long enough or maybe some smart algorithm that detangles the system, without requiring net information exchange with the outer world.
In contrast, I can also imagine starting with a system in an non-zero entropy state. You can create small pockets of low entropy (e.g. inside your favorite Stern-Gerlach experiment or quantum computer), but even maximally unentangling your states, reaching the fully unentangled state will be impossible. The von Neumann entropy is > 0, so states where the net entropy = 0 are fundamentally unattainable.
Therefore the question: which of these cases is our universe?
Do we have a way to estimate the net quantum information per particle?
We usually think of impure states as just entanglements with the environment, but is there something that would prevent the universe from being in an inherently impure state (not entangled with anything else), or what would be the consequence of such an impurity?