This is a highly philosophical question. Usually I try to avoid those, but now I am a bit tempted. I would like to share my thoughts, thoughts that are not in any way special and are taught in introductory courses of quantum field theory. I am not sure to what extend I will cover your concerns, but more experienced people can also comment/reply.
If one imagines flat spacetime as some background on which a set of "quantum fields" live, and all particles that can be thought of as excitations of those fields (fermions as excitations of spinor fields, photons as excitations of gauge fields etc) and their interactions to be happening in a way such that the world we live in occurs (imagine a world without gravity, because attempts are currently going on to interprete gravity as a quantum field, but they are not so successful yet), then one can set up experiments, just like the ones being conducted at CERN to measure specific properties of quantum field excitations or simply particles by making them collide.
A lot of results for the abovementioned measurements of the properties at hand have been verified to a great extend (see magnetic moment of electron for instance). Nevertheless, no one is telling us that the world we live in is a spacetime filled with quantum fields. The "quantum fields" are merely a description, constructed by us, to explain what we see in various experiments. This description is contstructed using a mathematical language (i.e. fields being spacetime functions that obey some algebra relations)...
So, in all I wouldn't say that one perspective contradicts the other. Yes, the framework of quantum field theory is a human construct, but it does not fail to explain the world around us (all the forces of nature except one: gravity). It is formulated in a concise mathematical language, yes, but this does not mean that there is no physical meaning in whatever mathematical objects/structures there exist in that framework... For reference I would advice you to read any quantum field theory textbook (I list some of them below) and be patient, as understanding some concepts may require some time. I also happened to see a nice lecture from David Tong.
Books on QFT (some of them are pretty heavy on mathematics):
Peskin and Schroeder: An introduction to quantum field theory
Srednicki: Quantum Field Theory
Sidney Coleman: Lectures of Quantum Field Theory
Weinberg: The Quantum Theory of Fields