Chappuis (French: [ʃa.pɥi]) is a French-language surname from the Arpitan region of eastern France and Francophone Switzerland with various spellings. Notable people with the surname include:
- Robert "Bob" Richard Chappuis (1923–2012), American football player
 - Charyl Chappuis, Swiss-Thai footballer
 - Eduardo Dibós Chappuis (called "Chachi"), Peruvian politician
 - Eliane Cat-Tuong Chappuis (born 1978), model, actress, singer, producer of Swiss descent
 - Friedrich-Wilhelm von Chappuis (1886–1942), General der Infanterie
 - James Chappuis (1854–1934), French chemist
 - Jason Lamy-Chappuis (born 1986, Missoula, Montana, USA), Franco-American ski jumper and cross-country skier
 - Liliane Chappuis (1955–2007), Swiss politician
 - Marie de Sales Chappuis, aka Marie-Thérèse Chappuis, Roman Catholic abbess
 - Paul Emile Chappuis (1816–1887), French photographer, inventor, and manufacturer
 - Philippe Chappuis (born 1967), Swiss comics creator
 - Eustace Chapuys (c. 1490/92–21 January 1556), Savoyard diplomat
 
There is also a scientific term named after the French chemist James Chappuis.
- Chappuis absorption, absorption bands in the ozone layer
 
See also
- Musée Chappuis-Fähndrich, Develier, Canton of Jura, Switzerland
 - Chapuis
 
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