Chapuis is a French-language surname of the Arpitan region of eastern France and Francophone Switzerland with various spellings. Notable people with the surname include:
- Bernard Chapuis (born 1945), French writer
 - Charles Bertin Gaston Chapuis de Tourville (1740–1809), French general
 - Cyril Chapuis (born 1979), French footballer
 - Félicien Chapuis (1824–1879), Belgian doctor and entomologist
 - Jean-Frédéric Chapuis (born 1989), French skier
 - Jean-Joseph Chapuis (1765–1864), French cabinetmaker
 - Johann Chapuis (born 1975), French footballer
 - Michel Chapuis (organist) (1930–2017), French organist
 - Michel Chapuis (born 1941), French canoeist
 - Olivier Chapuis (born 1975), French ice dancer
 - René-Bernard Chapuy (1746–1809, known as Chapuis), French soldier and general
 - Simone Chapuis-Bischof, (born 1931), Swiss women's rights activist
 
See also
- Chappuis (disambiguation)
 - Eustace Chapuys, Imperial ambassador to England from 1529 until 1545
 
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