The existing answers have quite an elegant idea behind them. However, my concern is that they don't seem to allow for the introduction of an ancilla. If we introduced an ancilla in a fixed state, and applied a unitary across the two systems, then it could be that all the eigenvectors are entangled across the two subsystems, and the basic argument wouldn't apply since we'd only be trying to make an argument about a separable input.
The way that I would approach such a calculation (I'll do it only for a single qubit here. That's sufficient to make the necessary argument, but you could extend it to any Hilbert space if you wanted). Let $\Phi$ be the Choi map of our operation. This means that, for an input state $|\psi\rangle$, the output state would be
$$
\rho_{\psi}=2\text{Tr}_1(|\psi\rangle\langle\psi|^T\otimes I\cdot\Phi).
$$
This is successful if
$$
\text{Tr}((I-|\psi\rangle\langle\psi|)\rho_{\psi})=1.
$$
Now, we need this to be true for all possible input states $|\psi\rangle=\cos\frac{\theta}{2}|0\rangle+\sin\frac{\theta}{2}e^{i\phi}|0\rangle$, so the average over all possible input states must also be 1. In other words, we want
$$
\frac{1}{2\pi}\int_0^{2\pi}d\phi\int_0^{\pi}\sin\theta d\theta\ \text{Tr}\left(|\psi\rangle\langle\psi|^T\otimes(I-|\psi\rangle\langle\psi|)\Phi\right)=1.
$$
If we work this out, it means that we require
$$
\text{Tr}\left(M\Phi\right)=1
$$
where
$$
M=\left(\begin{array}{cccc}
\frac{1}{3} & 0 & 0 & -\frac{1}{3} \\
0 & \frac{2}{3} & 0 & 0 \\
0 & 0 & \frac{2}{3} & 0 \\
-\frac13 & 0 & 0 & \frac13
\end{array}\right).
$$
So, what's the best choice of $\Phi$? It's an eigenvector of maximum eigenvalue of $M$. But the maximum eigenvalue is $\frac23$, meaning that it is impossible to achieve $\text{Tr}(M\Phi)>\frac23$, and hence it is impossible to give an orthogonal output for all possible single-qubit input states.
By way of contrast, if we restrict to just real states (i.e. $\phi=0$), the maximum eigenvalue of $M$ is larger that 1, which leaves open the possibility for creating an orthogonal state, which we know is possible just by applying Pauli-$Y$. This corresponds with $\Phi=(I\otimes Y)|B_{00}\rangle\langle B_{00}|(I\otimes Y)$.