Often when physics students are introduced to the HUP for position and momentum, the interpretation is that you aren't able to measure position and momentum for a particle to arbitrary precision at the same time. However, a better interpretation that works conceptually even without talking about measurements, is to accept that particles are waves and waves just do not have properties like position or momentum intrinsically. They are kind of emergent properties if you shape the waves the right way, and measure the right way.
(A) The HUP for energy and momentum also has a sort of "school-ish" interpretation. For instance in the book by Aitchison and Hey chapter 1.3. Here they say that two exact measurements of energy of a system will fluctuate more ($\Delta E$) the shorter the time the measuring device is interacting with the system ($\Delta t$), and that the two measurements will only yield the same results in the limit where the measuring device is interacting forever ($\Delta t \longrightarrow \infty$). They don't really explain why, beyond invoking the HUP equation.
(B) In QFT, virtual particles can be off-shell and have any energy they want, and this is explained via the HUP. Virtual particles can "borrow energy from the vacuum," provided they give it back shortly after. This is the interpretation I see again and again in the QFT litterature.
The first explanation (A) I can kinda follow, but ultimately it's not very precise. Also, it's very measurement dependent, and doesn't really give insight into what's going on in the particle waves/fields. Both waves and fields have intrinsic energies, right?
The second explanation (B) seems almost ridiculous to me. Particles can borrow energy? Does that concentrate energy in the vicinity of the particle? Can it borrow enough to create a black hole? How does it know that it has to give it back in a time interval according to the HUP equation? What am I missing?