Given the coupling costant $\alpha_s$ of QCD and it's RGE equation $\frac{d\ln \alpha_s(\mu^2)}{d\ln\mu^2}=\beta(\alpha_s)$, with $\beta(\alpha_s)=-\beta_0\alpha_s-\beta_1\alpha_s^2 -\beta_2\alpha_s^3+ \dots$ the perturbative expansion of the beta function. It can be proved that only the first two coefficents $\beta_0$ $\beta_1$ are independent by the renormalization scheme.
The positivity of the first beta coefficent is directly related to the property of asymptotic freedom, since $\alpha_s(\mu^2)$ decrease with $\mu^2$ only for $\beta_0>0$. So it is nice that this coefficent is independent by the renormalization scheme, given it's relation to a physical phenomenon.
My questions are the following
Does exist a physical phenomenon directly related to some property of the second beta coefficent? Such as for the first one. A property that makes important the fact that the related coefficent is independent by the renormalization scheme.
why it shouldn't bother me that the others coefficents are not independent by the renormalization scheme? They contributes to $\mu^2$ dependence of the coupling constant which is a property that can be measured experimentally. The only solution I can see is that, order by order, the terms that are different in the different renormalization schemes cancel out. In such a way the full beta function is scheme independent, and so there are no problems concerning the evolution of $\alpha_(\mu^2)$. Is this correct?