The first hint is in the well-known fact that the Laplace-Runge-Lenz (LRL) vector is always along the perihelion, that is to say that it is the direction of the major axis of the ellipse. The second hint is that with a potential
$$V(r) \propto \frac{1}{r^{1+\epsilon}},$$
however small is $\epsilon > 0$, the non-circular orbits are not closed: the perihelion precesses, which can be shown to correspond to a slow rotation of the LRL vector. Thus it can be said that the conservation of the LRL is intimately linked with the fact that the orbit closes.
However the Keplerian potential is not the only one with closed orbits: the 3D harmonic potential
$$V(r) = k r,$$
also has that property (those two potentials are the only ones with that property that all orbits are closed: this is Bertrand's theorem). However the extra conserved quantity in this case is not the LRL vector but an unrelated tensor, specifically,
$$T_{ij} = \frac{p_ip_j}{2m}+\frac{kr_ir_j}{2}.$$
This symmetric tensor brings two orthogonal axes of symmetry to the orbits instead of just one in the Keplerian case. Thus my statement above can be refined by stating that the LRL vector is associated with closed orbits with only one axis of symmetry.