That is, if we were approaching an HI or HII region in a spaceship, would the cloud have a color visible to the naked eye? Of the HI region, Wikipedia says:
These regions do not emit detectable visible light (except in spectral lines from elements other than hydrogen) but are observed by the 21-cm (1,420 MHz) region spectral line. This line has a very low transition probability, so requires large amounts of hydrogen gas for it to be seen.
But I'm not sure what it means by "so requires large amounts of hydrogen gas for it to be seen." What does "except in spectral lines from elements other than hydrogen" entail?