(See here for notation.) In Minkowski space, if $p\prec q$, then there is no spacelike curve $c:[0,1]\to \mathbb{R}^{n-1,1}$ with $c(0)=p$ and $c(1)=q$. This is obvious from a spacetime diagram. Here a "spacelike curve" is a $C^1$ mapping from a nondegenerate inverval into a Lorentzian manifold with everywhere spacelike tangent vector.
Take the cylinder $M=S^1\times\mathbb{R}$ with the Lorentzian metric $\mathrm{d}s^2=-\mathrm{d}\theta^2+\mathrm{d}t^2$. This spacetime is not causal, the circles $t=\mathrm{const.}$ are closed timelike curves. Let $\Sigma$ be a "surface" of constant $\theta$. It is clear that if $p,q\in\Sigma$, then there exists a spacelike curve $c$ connecting the two. But if they are close enough, then there exists a timelike curve $\lambda$ connecting the two as well. So $p\prec q$ (or the other way around). Thus the above result for Minkowski space does not apply to all spacetimes.
Thus my question is: what are the necessary and sufficient conditions on the spacetime topology and metric so that $p\prec q$ $\implies$ there exists no spacelike curve connecting $p$ and $q$?
Some observations: $J^+(p)\neq M$ for any $p$ is necessary. (Otherwise $p\prec q$ for all $q\in M$, in particular those connected to $p$ by a spacelike curve.) So $M$ should be causal, and probably even strongly causal. Perhaps one can reverse the question: if $p,q$ can be connected by a spacelike curve, what are the conditions for which $p\not\prec q$? Then, suppose $p$ and $q$ are contained in a Cauchy surface. There is a spacelike curve connecting them, but they cannot be connected by a causal curve because a causal curve intersects a Cauchy surface once.