A given thermodynamical system has a number of state variables, not all of which are independent. Suppose that we have a system which can be specified by $k+1$ extensive variables: $U,X_1,\cdots,X_k$. We also have $k$ intensive variables which are conjugate to the $k$ extensive variables $X_i$. To what extent are these $2k+1$ variables independent?
For example, we can always express the internal energy in terms of its natural variables: $$U=U(S,V,N_1,\cdots, N_{k-2})$$ But what about in terms of other variables? How about exchanging an extensive variable for its conjugate internal variable, say $T$ in place of $S$: $$U=U(T,V,N_1,\cdots,N_{k-2})?$$ Or perhaps replacing $T$ by some unrelated intensive variable, say $p$ in place of $S$: $$U=U(p,V,N_1,\cdots,N_{k-2})?$$ Will any combination of the remaining thermodynamic variables serve to functionally determine $U$? If not, then what exactly relates these $2k+1$ variables?