Apparently, in common law, a loan given without an interest being specified/demanded is at procedural disadvantage, in that a court may not recognize it as a contract, the plaintiff having to rely on promissory estoppel instead, in this case, at least according to Investopedia:
Promissory Estoppel as a Part of Contract Law
Contract law generally requires that a person receive consideration for making a promise or agreement. Legal consideration is a valuable asset that is exchanged between two parties to a contract at the time of a promise or agreement.
Ordinarily, some form of consideration, either an exchange of money or a promise to refrain from some action, is required for a contract to be legally enforceable. However, in attempting to ensure justice or fairness, a court may enforce a promise even in the absence of any consideration, provided that the promise was reasonably relied on and that reliance on the promise resulted in a detriment to the promisee.
It seems pretty obvious to me that not getting back the money lent is "a detriment to the promisee".
Are there quantitative or (lacking those) qualitative (e.g. comparative case) studies whether a zero-interest loan is a true disadvantage in the US court system, regarding repayment, ceteris paribus (i.e. assuming otherwise the same basic conditions are met, e.g. evidence [like witnesses and/or a written note] to prove that the promise to repay was made on a certain date/event or schedule)? Or is the lack of interest [demanded] rather irrelevant in practice, as far as trial outcomes? I'd prefer we limit the discussion to the US, but if clear-enough evidence (one way or the other) is only available from other common-law jurisdictions, I'd accept an answer based on a proxy jurisdiction.
I'm not sure if this self-answers my Q (I would like more evidence) but LII Wex says in broad terms that:
An agreement made by promissory estoppel will typically have the same binding effects on parties that a valid contract would.
(N.B. Another source says that promissory estoppel "was formally “ushered” onto the stage of American contract law in 1932". So I guess evidence has to be after that year...)