Wyne may refer to:
People
Surname
- Ehsan Wyne (born 1938), Pakistani lawyer and political figure
 - Ghulam Haider Wyne (1940–1993), Pakistani politician and Chief Minister of Punjab
 - Wyne Lay (born 1994), Burmese singer-songwriter and model
 - Begum Majeeda Wyne, Pakistani politician, wife of Ghulam Haider Wyne
 - Zaneta Wyne (born 1990), American soccer player
 
Other
- Wyne Su Khine Thein (born 1986), Burmese singer and actress
 - Wyne (film director), Burmese filmmaker Tun Zaw Win (born 1973)
 
Radio stations
- WYNE-LP, a low-power radio station (95.9 FM) licensed to serve Wayne, New Jersey, United States
 - WZTE, a radio station (1530 AM) licensed to serve North East, Pennsylvania, United States, which held the call sign WYNE from 2004 to 2013
 - WHBY, a radio station (1150 AM) licensed to serve Kimberly, Wisconsin, United States, which held the call sign WYNE until 1992
 
Other uses
- Wyna (river), a river in Switzerland also known as the Wyne
 - Wyne (tribe), a Jat Muslim tribe of Pakistan
 
See also
- Wyn, a surname
 - Wynne (disambiguation)
 - Wine (disambiguation)
 
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