WPB may refer to:
- War Production Board, a US government agency in WWII
- War Propaganda Bureau of Britain's Foreign Office in WWI
- Weekly Playboy, Japanese men's magazine
- Weibel–Palade body, storage granules of endothelial cells
- West Palm Beach, Florida, United States, a city
- World Painted Blood, a 2009 album by the thrash metal band Slayer
- Waste paper basket
- The hull classification symbol of an Island-class patrol boat of the US Coast Guard
- Port Bergé Airport, Madagascar
- World Prison Brief, database of prison systems throughout the world
- Whizz Pop Bang, a science magazine for children
Political parties
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