Tyldesley is a town in Greater Manchester, England
Tyldesley may also refer to:
- Tyldesley (ward), an electoral ward of the Wigan Metropolitan Borough Council
 
People
- Addin Tyldesley (1878-1962), British swimmer
 - Catherine Tyldesley (born 1983), British actress and model
 - Clive Tyldesley (born 1954), British sports commentator
 - Dick Tyldesley (1897–1943), Lancashire cricketer, unrelated to Johnny or Ernest
 - Ernest Tyldesley (1889–1962), Lancashire County Cricket Club's highest run scorer, brother of Johnny
 - Johnny Tyldesley (1873–1930), Lancashire County Cricket Club player, brother of Ernest
 - Joyce Tyldesley, English archaeologist
 - Thomas Tyldesley (1612–1651), Royalist commander in the English Civil War
 - Thurstan Tyldesley, English MP
 
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