Thomas Willis (1621–1675) was an English physician and anatomist.
Thomas Willis may also refer to:
- Thomas Willis (Clerk of the Crown in Chancery) (1576–1656), high-ranking official during the English Civil War
 - Thomas H. Willis (1850–1925), American painter
 - Tom Willis (soccer) (born 1983), Australian goalkeeper
 - Tom Willis (rugby union, born 1979), New Zealand rugby union player
 - Tom Willis (rugby union, born 1999), England rugby union player
 - Thomas Willis (sailor) (1756–1797), sailor with the second voyage of James Cook
 - Tom Willis (The Jeffersons), character in the American sitcom The Jeffersons
 
See also
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