Thomas Osborne may refer to:
- Thomas Osborne, 1st Duke of Leeds (1632–1712), English Lord High Treasurer, Lord President of the Council and MP for York
- Sir Thomas Osborne, 5th Baronet (1639–1715), Irish baronet and landowner
- Thomas Osborne (publisher) (1704?–1767), English publisher and bookseller
- Thomas Osborne, 4th Duke of Leeds (1713–1789), British Justice in Eyre and Cofferer of the Household
- Sir Thomas Osborne, 9th Baronet (1757–1821), Irish baronet and politician
- Thomas Burr Osborne (politician) (1798–1869), U.S. Representative from Connecticut
- Thomas Osborne (Australian journalist) (c. 1806–1853), Australian journalist and politician in the Victorian Legislative Council
- Thomas W. Osborn (1833–1898), U.S. Senator from Florida
- Thomas O. Osborn (1832–1904), American lawyer, soldier, and diplomat
- Thomas A. Osborn (1836–1898), Governor of Kansas
- Thomas Mott Osborne (1859–1926), American prison reformer
- Thomas Burr Osborne (chemist) (1859–1929), chemist, co-discoverer of Vitamin A
- Tom Osborne (born 1937), US college football head coach and member of Congress
- Tom Osborne (Canadian politician) (born 1964), Newfoundland and Labrador politician
- Tom Osborne (American football, born 1960), American football coach
- Tom Osborne (engineer), American engineer who created the Green Machine which led to the Hewlett-Packard 9100A
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