Tedesco (Italian for "German") may refer to:
- 2882 Tedesco, main-belt asteroid
 - Tedesco gin, a variant of gin rummy
 - Fondaco dei Tedeschi, headquarters and restricted living quarters of the German merchant population in Venice
 - Germans, an ethnic group native to Germany
 - The German language, a West Germanic language spoken in Germany, Austria, Switzerland, Liechtenstein, Belgium, Luxembourg, South Tyrol, Lorraine, and Alsace
 - Tedesco (surname)
 - Uva Tedesco, synonym for the Italian wine grape Marzemino
 
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