Spillane is a family name derived from the Irish (Gaelic) surname Ó Spealáin or Mac Spealáin. It has also been anglicised as Spellman, Spillan, Spilane and Spallon. It may refer to:
People
- Adrian Spillane (born 1994), Gaelic footballer from Ireland
 - Daniel Spillane (born 1980), finalist on Australian Idol 2005
 - Davy Spillane (born 1959), Irish musician, player of uilleann bagpipes
 - Debbie Spillane (born 1955), Australian sports journalist and broadcaster
 - James Spillane, American politician from New Hampshire
 - John Spillane (born 1961), singer/songwriter from Cork, Ireland
 - John David Spillane (1909–1985), Welsh physician
 - Johnny Spillane (born 1980), American Nordic combined skier
 - Killian Spillane, Gaelic footballer from Ireland
 - Michael Spillane (footballer) (born 1989), Irish soccer player
 - Mickey Spillane (1918 – 2006), American author of crime novels
 - Mickey Spillane (gangster) (1934 - 1977), Irish-American mobster from New York
 - Nicole Spillane (born 1988), French and Irish applied mathematician
 - Pat Spillane (born 1955), Gaelic footballer from Ireland
 - Robert Spillane (born 1995), American football player
 - Scott Spillane, American musician
 - Tom Spillane (born 1962), Gaelic footballer from Ireland
 
Other
- Spillane (album), an album by John Zorn dedicated to writer Mickey Spillane
 
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