Sofronie may refer to:
Name
- Sofronie of Cioara, Romanian Orthodox saint
 - Sofronie Drincec (born 1967), Romanian bishop
 - Sofronie Vârnav, Moldavian and Romanian political figure, philanthropist, collector, and Orthodox clergyman
 - Sofronie Vulpescu (1856 – 1923), Romanian cleric
 
Surname
- Nicoleta Daniela Șofronie (born 1988), Romanian artistic gymnast
 
See also
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