Sisulu is a surname. People with this surname include:
- Albertina Sisulu (1918–2011), anti–apartheid activist
 - Lindiwe Sisulu (born 1954), South African Minister of Defence and Military Veterans
 - Max Sisulu (born 1945), Speaker of the National Assembly of South Africa
 - Samuel Sisulu (1956-2003), South African anti-apartheid activist, Soweto uprising student leader and founder of South African Freedom Organisation (SAFO)
 - Walter Sisulu (1912–2003), Secretary-General of the African National Congress
 - Zwelakhe Sisulu (1950-2012), South African journalist, editor, newspaper founder, CEO of SABC, and businessperson
 
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