Sebastiano is both a masculine Italian given name and a surname. Notable people with the name include:
- Sebastiano Antonio Tanara (1650–1724), Italian cardinal
 - Sebastiano Baggio (1913–1993), Italian clergyman
 - Sebastiano Bianchi (16th century), Italian engraver
 - Sebastiano Bombelli (1635–1724), Italian painter
 - Sebastiano Brunetti (died 1649), Italian painter
 - Sebastiano Caracciolo (1922–2013), Italian Freemason
 - Sebastiano Carezo (fl. 1780), Spanish dancer (Sebastián Cerezo)
 - Sebastiano Conca (c. 1680 – 1764), Italian painter
 - Sebastiano Dolci (1699–1777), Croatian writer
 - Sebastiano Esposito (born 2002), Italian footballer
 - Sebastiano Filippi (c. 1536 – 1602), Italian late Renaissance-Mannerist painter
 - Sebastiano Galeotti (1656–1746), Italian painter
 - Sebastiano Ghezzi (1580–1645), Italian painter and architect
 - Sebastiano Guala (17th century), Italian church architect
 - Sebastiano Giuseppe Locati (1861–1939), Italian architect
 - Sebastiano Martinelli (1848–1918), Cardinal of the Roman Catholic Church
 - Sebastiano Mazzoni (c. 1611 – 1678), Italian painter
 - Sebastiano Mocenigo (1662–1732), Doge of Venice
 - Sebastiano Nela (born 1961), Italian ex-footballer
 - Sebastiano Pinna (born 1971), Italian ex-footballer
 - Sebastiano del Piombo (c. 1485 – 1547), Italian Renaissance-Mannerist painter
 - Sebastiano Ricci (1659–1834), Italian painter
 - Sebastiano Rossi (born 1964), Italian footballer
 - Sebastiano Santi (1788–1866), Italian painter
 - Sebastiano Serafini, Italian actor, model, and musician
 - Sebastiano Serlio (c. 1475 – 1554), Italian Mannerist architect
 - Sebastiano Siviglia (born 1973), Italian football defender
 - Sebastiano Taricco (1645–1710), Italian painter
 - Sebastiano Timpanaro (1923–2000), Italian classical philologist, essayist, and literary critic
 - Sebastiano Venier (c. 1496 – 1578), Doge of Venice
 - Sebastiano Visconti Prasca (1883–1961), Italian military officer
 - Sebastiano Ximenes (16th century), Italian banker
 - Sebastiano Ziani (12th century), Doge of Venice
 - Richiardi Sebastiano (1834–1904), Italian anatomist and zoologist
 
See also
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