Samuel or Sam Cooke may refer to:
- Samuel Cooke (Australian politician) (1847–1929)
 - Sam Cooke (1931–1964), American singer
 - Samuel Cooke (judge) (1912–1978), English judge
 - Sam Cooke (model) (born 1985), English glamour model
 - Sam Cooke (Australian footballer) (1883–1966), Australian rules footballer
 - S. S. Cooke (Samuel Stephen Cooke Sr., 1879–1944), college football coach
 - S. N. Cooke (Samuel Nathaniel Cooke Jr., 1883–1964), English architect
 - Samuel Cooke and Co, oil and fuel delivery and manufacture service
 - Sir Samuel Cooke, 1st Baronet (c. 1690–1758), Anglo-Irish politician
 
See also
- Samuel Cook (disambiguation)
 - Cooke (surname)
 - Sam Koch, pronounced the same way
 
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