S1, S01, S.I, S-1, S.1, Š-1 or S 1 may refer to:
Biology and chemistry
- S1 nuclease, an enzyme that digests singled-stranded DNA and RNA
 - S1: Keep locked up, a safety phrase in chemistry
 - Primary somatosensory cortex, also known as S1
 - Tegafur/gimeracil/oteracil, also known as S-1, a chemotherapy medication
 
Entertainment
- S1 (Indian TV channel), a Hindi-language channel
 - S1 (Swiss TV channel), a German-language channel
 - S1 (producer), a hip hop producer, member of the group Strange Fruit Project
 - S1 No. 1 Style, a Japanese adult video company
 - Gibson S-1, a guitar made by the Gibson Guitar Corporation
 - A member of the S1W (group) that later became part of the music group Public Enemy.
 
Government
- Bill S-1, a pro forma bill in Canadian Parliament
 - Form S-1, a U.S. Securities and Exchange Commission filing
 - S-1 Executive Committee, a United States government entity during World War II
 - S1 (military), an administrative position within military units
 
Technology
- ACPI S1 power state, in computing; see Advanced Configuration and Power Interface § Global states
 - Apple S1, integrated computer used in the Apple Watch
 - Canon PowerShot S1 IS, a 2004 3.2 megapixel digital camera
 - FinePix S1 Pro, a 2000 interchangeable lens digital single-lens reflex camera by Fujifilm
 - Nikon Coolpix S1, a digital camera
 - S1 Corporation, an American software development company
 - S1 Core, a microprocessor-core
 - S1 MP3 Player
 - Samsung Galaxy S (2010 smartphone)
 - Sendo S1, a Sendo mobile phone model
 - Siemens S1, a Siemens mobile phone
 - Sony BDP-S1, a first generation Blu-ray Disc (BD) Player
 - S1, an EPC in an LTE/4G network
 
Transportation
Routes
China
Germany
- S1 (Berlin), an S-Bahn line
 - S1 (Dresden), an S-Bahn line
 - S1 (Munich), an S-Bahn line
 - S1 (Nuremberg), an S-Bahn line
 - S1 (Rhine-Main S-Bahn), an S-Bahn line
 - S1 (Rhine-Ruhr S-Bahn), an S-Bahn line
 - S1 (Stuttgart), an S-Bahn line
 - a planned Bremen S-Bahn line
 - a Hamburg S-Bahn line
 - a Hanover S-Bahn line
 - a RheinNeckar S-Bahn line
 - a Rostock S-Bahn line
 - a Stadtbahn Karlsruhe line
 
Switzerland
- S1 (Bern S-Bahn), an S-Bahn line in the canton of Bern
 - S1 (RER Vaud), an S-Bahn line in the canton of Vaud
 - S1 (St. Gallen S-Bahn), an S-Bahn line in the canton of St. Gallen
 - S1 (ZVV), now subsumed by S24, a Zürich S-Bahn line
 
United States
Other countries
- S1 (Vienna), an S-Bahn line in Austria
 - Line S1 (Milan suburban railway service), Italy
 - S-1 Strategic Highway, Pakistan
 - Expressway S1 (Poland)
 - FGC line S1, a suburban train line in Barcelona Province, Spain
 - Stagecoach Gold bus route S1, in Oxfordshire, England, UK
 
Vehicles
Aircraft
- Blackburn Buccaneer S.1 jet naval strike aircraft
 - Focke-Wulf S 1, a German Focke-Wulf aircraft
 - Fokker S.I, a 1919 Dutch primary trainer aircraft
 - Hopfner S-1, a Hopfner aircraft
 - Letov S-1, a 1920 Czechoslovak surveillance aircraft
 - Loening S-1, a United States Army Air Service seaplane
 - Loughead S-1 Sport 1920 US biplane
 - Martinsyde S.1, a 1914 British biplane aircraft
 - Pantsir-S1, a Russian anti-aircraft system
 - Pitts S-1 aerobatic biplane
 - S-1 Loening, a United States Army Air Service seaplane
 - SSBS S1, a French experimental rocket
 - Swift S-1, a 1991 Polish single seat aerobatic glider
 
Cars
- AS S1, a 1927 car manufactured in Poland
 - Audi S1, performance variant of Audi A1
 - Invicta S1, a 2004 sports car
 - Leapmotor S01, an all-electric car
 - S1 Scout Car, an armoured car built in Australia during the Second World War
 - Superformance S1 Roadster, a Lotus Seven Type replicar produced in South Africa 2001–2004
 - Saleen S1, an American sports car
 
Other vehicles
- Alco S-1, a locomotive
 - PRR S1, a duplex locomotive developed by the Pennsylvania Railroad
 - LNER Class S1, a class of British steam locomotives
 - NER Class S1, a class of British steam locomotives
 - USS S-1 (SS-105), a 1918 United States Navy experimental submarine
 
Other uses
- S1 (classification), a disability swimming classification
 - S postcode area covering Sheffield City Centre
 - in human anatomy:
 
- the first sacral vertebra
 - the sacral spinal nerve 1 of the vertebral column
 - the primary somatosensory cortex in the brain
 
- Senior 1, the First Year in the Scottish secondary education system
 - Season (television) or series one
 - Comet Ikeya-Seki, C/1965 S1
 - Upplands regemente (signal), a 1902 Signal Regiment of the Swedish Armed Forces
 
With superscripts and subscripts
S1 may refer to :
- S1 (heart sound), a heart sound in cardiac auscultation
 
S1 may refer to :
- S1, the n-sphere in two dimensions i.e. a circle
 - Inverse second (s−1), a unit of frequency
 
S01
S01 may refer to :
- Akai S01, an Akai synthesizer
 - ATC code S01 Ophthalmologicals, a subgroup of the Anatomical Therapeutic Chemical Classification System
 - HMS Porpoise (S01), a 1956 Porpoise-class submarine of the Royal Navy
 - MULTI-S01, an encryption algorithm based on a pseudorandom number generator
 
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