R5 may refer to:

Roads or railroads

• Autopista Radial R-5, a Spanish radial motorway
• R5 (RER Vaud), an S-Bahn line in the canton of Vaud
• R5 expressway (Slovakia)
• R5 road (Zimbabwe), a road connecting Harare with Mutare
• Radial Road 5 or R-5, an arterial road of Manila, Philippines
• Line R5, a commuter rail service on the Llobregat–Anoia Line, in Barcelona, Catalonia, Spain
• R5 Doylestown, a rail line in Philadelphia, USA
• R5 Paoli-Thorndale, a rail line in Philadelphia, USA

Ships

• HMS Invincible (R05), a 1980 British Royal Navy light aircraft carrier
• HMS Urania (R05), a World War II British Royal Navy U-class destroyer
• USS R-5 (SS-82), a 1918 R-class coastal and harbor defense submarine of the United States Navy

Cars

• Jaguar R5, a Jaguar Racing car for the 2004 Formula One season
• Renault 5, a French automobile
• R5 (rallying) a class within Group R regulations for rallying

Aircraft

• Kinner R-5, a popular engine for light general and sport aircraft
• Polikarpov R-5, a reconnaissance biplane widespread in the Soviet Union before World War II
• Sikorsky R-5, an early USAF designation of Sikorsky S-51 helicopter, changed to H-5
• Thomas-Morse R-5, a 1920s American racing aircraft

Buildings

• Regjeringskvartalet, a building in the Norwegian Government quarter (Norw. Regjeringskvartalet)

Weapons

• R5 assault rifle, a variant of the South African R4 assault rifle compact carbine
• R-5 Pobeda, a theatre ballistic missile developed by the Soviet Union during the Cold War

Medicine and chemistry

• R5 virus, a form of HIV tropism
• ATC code R05 Cough and cold preparations, a subgroup of the Anatomical Therapeutic Chemical Classification System
• Cough ICD-10
• R5: Heating may cause an explosion, a risk phrase in chemistry
• receptor 5, the fifth in line of a series of cellular receptors, generally at the end of an acronym

Other uses

• R5 (band), an American pop-rock band
• R5 (bootleg), a copy of a movie made with a telecine machine from an analog source
• Region 5, the DVD region code for most of Africa, Asia, and the former Soviet Union
• BBC Radio 5 Live, a British radio station
• Jordan Aviation, IATA airline designator
• Malta Air Charter, former IATA airline designator
• R5 series of preferred numbers
• Radeon R5, graphics processing units in the Radeon 200 series
• a type of droid from Star Wars, such as R5-D4
• R5 Hastings St, an express bus service in Metro Vancouver, British Columbia, Canada
• Canon EOS R5, a Canon full-frame mirrorless interchangeable-lens camera