R27 may refer to:
Missiles
- R-27 (air-to-air missile), a Soviet air-to-air missile
- R-27 Zyb, a Soviet submarine-launched ballistic missile
Roads
Other uses
- R27 (New York City Subway car)
- BMW R27, a motorcycle
- HMA R.27, a rigid airship of the Royal Air Force
- HMS Croziers (R27), a destroyer of the Royal Navy
- R27: Very toxic in contact with skin, a risk phrase
- Renault R27, a Formula One racing car
- Rubik R-27 Kópé, a Hungarian training glider
- USS R-27 (SS-104), a submarine of the United States Navy
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