Look up prickle in Wiktionary, the free dictionary.
Prickle may refer to:
- Thorns, spines, and prickles, a sharp, needle-like structures
- Prickle cell of the skin
- Prickle (protein), a planar cell polarity protein
- The collective noun for a pack of porcupines
- Prickle (Gumby character), a character on The Gumby Show
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