Sixtus is a Roman name, a corruption of the Greek name "Ξυστος", meaning "polished", and originally Latinized "Xystus". Its Spanish form is Sixto.
Popes
- Pope Sixtus I (115/116–125)
 - Pope Sixtus II (257–258)
 - Pope Sixtus III (432–440)
 - Pope Sixtus IV (1471–1484)
 - Pope Sixtus V (1585–1590)
 
Others
- Sixtus of Reims (d. c. 300), bishop of Reims
 - Sixtus of Esztergom (d. 1285/86), Hungarian clergyman
 - Sixtus of Siena (1520–1569), Jewish Roman Catholic theologian
 - Prince Sixtus of Bourbon-Parma (1886–1934)
 - Albert Sixtus (1892–1960), German children's writer
 - Edmund Sixtus Muskie (1914–1996), American statesmen, 58th United States Secretary of State 1980–81
 - Prince Sixtus Henry of Bourbon-Parma (born 1940)
 - Sixtus Lanner (1934–2022), Austrian politician
 - Sixtus Leung Chung-hang (born 1986), Hong Kong activist and politician
 
See also
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