Pollexfen is a British, South Devon surname associated and may refer to:
- Henry Pollexfen (1632–1691), British judge and politician
 - John Pollexfen (1636–1715), British merchant, political economist, and Justice-of-the-Peace
 - Jack Pollexfen (1908–2003), US screenwriter and film producer
 - Susan Pollexfen (1841-3–1900), wife of Irish artist John Butler Yeats
 
See also
- Edmund Pollexfen Bastard (1784–1838), British Tory politician
 - John Pollexfen Bastard (1756–1816), British Tory politician and colonel of the East Devonshire Militia
 
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