Pessina is an Italian surname. Notable people with the surname include:
- Giorgio Pessina (1902–1977), Italian fencer
- Giovanni Pessina (1836–1904), Italian painter
- Jean Pessina, Swiss slalom canoeist
- Matteo Pessina (born 1997), Italian footballer
- Stefano Pessina (born 1941), Italian-born Monegasque billionaire
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