Ōsugi, Osugi, Oosugi or Ohsugi (written: 大杉 lit. "big sugi") is a Japanese surname. Notable people with the surname include:

• Isamu Osugi, Japanese mixed martial artist
• Katsuo Osugi (大杉 勝男, 1945–1992), Japanese baseball player
• Kumiko Ōsugi (大杉 久美子, born 1951), Japanese singer
• Masato Osugi (大杉 誠人, born 1983), Japanese footballer
• Ren Osugi (大杉 漣, 1951–2018), Japanese actor
• Sakae Ōsugi (大杉 栄, 1885–1923), Japanese anarchist
• Tsutomu Oosugi (ツトム・オースギ, born 1985), Japanese professional wrestler

See also

• Ōsugi Station, a railway station in Ōtoyo, Nagaoka District, Kōchi Prefecture, Japan