Osse may refer to:
- Osse, Doubs, a commune of the Doubs département, in France
 - Ossé, a commune of the Ille-et-Vilaine département, in France
 - Osse, Łódź Voivodeship (central Poland)
 - Osse (river), a river in southwestern France
 - Den Osse, a village in the Netherlands
 - Office of the State Superintendent of Education in the District of Columbia Public Schools system (Washington, DC)
 - OSSE, Oriented Scintillation Spectrometer Experiment
 
See also
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