Opaline may refer to:
- Opaline, a group of protists
 - Opaline, an album by Dishwalla
 - Opaline glass, decorative French glass
 - Opaline silica: an amorphous or cryptocrystalline form of hydrated silica SiO2ยทnH2O (Opal)
 - Opaline, a colour mutation of the budgerigar, Melopsittacus undulatus
 
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