Nepomuk is a town in the Plzeň Region of the Czech Republic.
Nepomuk also may refer to:
- NEPOMUK (framework), software framework
 - Nepomuk (Příbram District), a village and municipality in the Central Bohemian Region of the Czech Republic
 - Nepomuk, fictional character in Thomas Mann's novel Doctor Faustus
 - John of Nepomuk, Czech saint
 
Nepomuk is also a part of the following given names invoking the saint:
- Johann Nepomuk David, Austrian composer
 - Johann Nepomuk della Croce, Austrian painter
 - Johann Nepomuk Fuchs (disambiguation), several people
 - Peter Johann Nepomuk Geiger, Viennese artist
 - Johannes Nepomuk Franz Xaver Gistel, German naturalist
 - Johann Nepomuk Hiedler, great-grandfather of Adolf Hitler
 - Johann Nepomuk Hofzinser, Austrian-Hungarian magician
 - Johann Nepomuk Hummel, Austrian composer and pianist
 - Johann Nepomuk Karl, Prince of Liechtenstein
 - Johann Nepomuk Maelzel, German inventor
 - Johann Nepomuk Eduard Ambrosius Nestroy, Austrian writer and actor
 - Johann Nepomuk von Triva, German general
 - Johann Nepomuk von Tschiderer zu Gleifheim, Austro-Italian bishop
 
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