Nafisi is an Iranian surname. Notable people with the surname include:
- Abdullah Al-Nafisi (born 1945), Kuwaiti academic and politician
 - Ahmad Nafisi (1919–2004), Iranian bureaucrat and mayor of Tehran (1961–1963)
 - Amannisa Khan Nafisi, wife of Abdurashid Khan (1526-1560)
 - Azar Nafisi (born 1948), Iranian-American writer and academic
 - Habib Nafisi (1908–1984), Iranian academic
 - Khalid Al-Nafisi (1937–2006), Kuwaiti actor
 - Nezhat Nafisi (1920–2003), Iranian politician
 - Saeed Nafisi (1895–1966), Iranian scholar, fiction writer and poet
 
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