A motherboard is the main printed circuit board in a computer.
Motherboard may also refer to:
- Motherboard cache, the storage component of a motherboard
 - Motherboard form factor, the specifications of a motherboard
 - Motherboard (Cyberchase), a character from Cyberchase
 - Motherboard (website), an online tech news publication by Vice Media
 - "Motherboard" (Daft Punk song), 2013 song in album Random Access Memories
 - Motherboard Monitor, a software program for Windows
 
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