McIntire is a surname. Notable people with the surname include:
- Albert McIntire (1853–1935), American politician from Colorado
 - Barbara McIntire (born 1935), American golfer
 - Carl McIntire (1906–2002), a founder and minister in the Bible Presbyterian Church
 - Clifford McIntire (1908–1974), US Congressman from Maine
 - Harry McIntire (John Reid McIntire) (1879–1949), pitcher for the Brooklyn Superbas
 - Henry McIntire (1835–1863), Union Army officer and lawyer
 - Jim McIntire, U.S. gunfighter, Texas Ranger in the Old West
 - John McIntire (1759–1815), founder of the city of Zanesville, Ohio
 - John McIntire (1907–1991), American character actor
 - Lani McIntyre aka Lani McIntire (1904–1951), a Hawaiian guitar and steel guitar player
 - Larry McIntire, American engineer
 - Lucy Barrow McIntire (1886–1967), American activist, preservationist, actor, and poet
 - Paul Goodloe McIntire (1860–1952), U.S. stock broker, investor, and philanthropist
 - Rufus McIntire (1784–1866), U.S. lawyer, congressman
 - Samuel McIntire (1757–1811), American architect and craftsman
 - Tim McIntire (1944–1986), American character actor
 - William Watson McIntire (1850–1912), U.S. Congressman from Maryland
 - George McIntire (2008-2023), Walmart Cashier, U.S, Arizona
 
Fictional characters
- Molly McIntire, character from the American Girl toy franchise
 
See also
- McIntire, Iowa, city in Mitchell County, Iowa, United States
 - Herman McIntire House, historic house in Quincy, Massachusetts
 - McIntire Garrison House, historic house in York, Maine
 - McIntire Investment Institute, student-run equity fund at the University of Virginia
 - McIntire–Stennis Act of 1962, for U.S. state agricultural experiment stations and forestry schools
 - McIntyre (disambiguation)
 - MacIntyre
 - Reba McEntire, US actress and country western singer
 
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