Masisi is a town in the Democratic Republic of the Congo.
Masisi may also refer to:
- Mokgweetsi Masisi, the fifth and current president of Botswana
 - Edison Masisi, a diplomat and politician from Botswana and the father of Mokgweetsi Masisi
 - Neo Masisi, the First Lady of Botswana and wife of Mokgweetsi Masisi
 - Love Masisi, Dutch drag queen
 - Masisi Territory, a territory around Masisi in the Democratic Republic of the Congo
 
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