This is a list of Amarilloans, notable current and former citizens of Amarillo, Texas.

Arts and entertainment

• Jennifer Archer, author
• Art Bell, radio host and author
• Lacey Brown, folk singer and American Idol finalist
• Gail Caldwell, Pulitzer Prize-winning book critic
• Derek Cecil, actor (Push, Nevada)
• Cyd Charisse, dancer and actress (The Band Wagon, Brigadoon)
• Ann Doran, actress (Rebel Without a Cause)
• Joe Ely, country and folk singer
• Ron Ely, actor (Tarzan)
• Todd English, celebrity chef
• Kevin Fowler, country music singer
• Blair Garner, country music radio host
• Jimmy Gilmer, rock singer ("Sugar Shack")
• Jimmie Dale Gilmore, country music singer
• Clyde Kenneth Harris, soldier and interior decorator
• Kimberly Willis Holt, author
• Mitchell Hurwitz, TV writer
• Sterling Hyltin, ballet dancer
• Carolyn Jones, actress (The Addams Family)
• Grady Nutt, comedian (Hee Haw)
• Hayden Pedigo, musician
• John Rich, guitar player
• Eck Robertson, musician
• Ben Sargent, Pulitzer Prize-winning editorial cartoonist
• George Saunders, writer, winner of Macarthur Fellowship Genius Grant
• J.D. Souther, country rock singer
• Terry LaVerne Stafford, songwriter
• Francie Swift, actress
• Jodi Thomas, author
• Paula Trickey, actress (Pacific Blue)
• Aaron Watson, country music singer
• Trent Willmon, country music singer
• Jack Wrather, television director
• M. K. Wren, mystery and science fiction writer
• Roger Miller, country music singer
• Arden Cho, actress

Business

• T. Boone Pickens, Jr., oilman and philanthropist

Law and government

• James R. Beverley, governor of Puerto Rico
• Teel Bivins, United States Ambassador to Sweden
• Beau Boulter, United States Congressman
• James Nathan Browning, Texas lieutenant governor
• Odell M. Conoley, USMC; Deputy Director for Operations, Plans, Policies and Operations Division, Staff of the Commander in Chief, United States European Command
• Jake Ellzey, United States Congressman
• Howard D. Graves, Superintendent of the U.S. Military Academy at West Point, later Chancellor of Texas A & M system of universities
• John Marvin Jones, United States Congressman and Chief Judge of the Court of Claims
• Walter Thomas Price, IV, Amarillo attorney and Republican nominee for the District 87 seat in the Texas House of Representatives
• Mary Lou Robinson, United States federal judge
• Kel Seliger, mayor and Texas state senator

Sports

• Rex Baxter, professional golfer and NCAA champion
• Trevor Brazile, PRCA All Around Cowboy
• Brad Bryant, professional golfer
• Paul Buentello, mixed martial artist
• Steve Butler, racecar driver
• Ron Clinkscale, professional Canadian football player
• Michael Cobbins (born 1992), basketball player for Maccabi Haifa of the Israeli Basketball Premier League
• Tucker Davidson, professional baseball player
• Bobby Duncum Jr., professional wrestler
• Dory Funk, professional wrestler
• Dory Funk, Jr., professional wrestler
• Terry Funk, professional wrestler
• Heath Herring, mixed martial artist
• Mike Hettinga, aka Mike Knox, professional wrestler
• Ziggy Hood, professional football player
• Heston Kjerstad, professional baseball player
• Wildcat Monte (born Monte Deadwiley; 1905–1961), professional boxer
• Alex O'Brien, professional tennis player
• Barry Orton, professional wrestler
• Ryan Palmer, professional golfer
• Bum Phillips, professional football coach
• Cody Pfister, mixed martial artist
• Chris Romero, professional wrestler
• Mark Romero, professional wrestler
• Ricky Romero, professional wrestler
• Steven Romero, professional wrestler
• Hurles Scales, professional football player
• Mike Scroggins, professional bowler
• Brandon Slay, gold-medal Olympic wrestler
• T.A. "Amarillo Slim" Preston, professional poker player
• Evan Tanner, professional mixed martial artist
• William Thomas, professional football player
• Devonte Upson (born 1993), basketball player in the Israeli Basketball Premier League
• Ken Vinyard, professional football player
• Erik Watts, professional wrestler
• Gene Wiley, professional basketball player

Others

Amarillo High School graduate Rick Husband, astronaut and the Space Shuttle commander of STS-107 (Columbia) who was killed when the craft disintegrated after reentry into the Earth's atmosphere

• Charles Albright, serial killer
• George Hendricks Beverley, U.S. Air Force general
• Thomas E. Creek, U.S. Marine Corps Medal of Honor recipient
• Brittany Holberg, convicted murderer who was sentenced to death row
• Rick Husband, astronaut
• Paul Lockhart, astronaut
• Leroy Matthiesen, local Catholic bishop
• Grady Booch, software engineer