LGN may refer to:
- Lateral geniculate nucleus, a component of the visual system in the brain's thalamus
- Longton railway station, the station code LGN
- lgn, the ISO 639-3 code for Opuo language
- La Gente Naranja, a Florida-based Ecuadorian Rock en Espanol music band
- GPSM2, a protein-coding gene in the species Homo sapiens
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