Keyes is a common surname, derived from either Anglo-Saxon tribe of Great Britain or a Celtic tribe of Ireland. Notable people with the name include:
- Alan Keyes (born 1950), American politician and diplomat
 - Ancel Keyes, American scientist who invented K-rations and popularized the Mediterranean diet
 - Baron Keyes, a title in the Peerage of the United Kingdom
 - Charles Henry Keyes (1858–1925), American educator
 - Charles Reuben Keyes (1871–1951), American archaeologist
 - Charles Rollin Keyes (1864–1942), American geologist, ornithologist, and politician
 - Christian Keyes (born 1975), American actor and model
 - Daniel Keyes (1927–2014), American author
 - Dan Keyes, American musician in the band Recover
 - Edward J. Keyes (1859–1929), American politician and farmer
 - Erasmus D. Keyes (1810–1895), American general
 - Evelyn Keyes (1916–2008), American actress
 - Frances Parkinson Keyes (1885–1970), American author
 - Geoffrey Charles Tasker Keyes VC (1917–1941), British Major killed in the raid on Rommel
 - Geoffrey Keyes (1888–1967), major general in the U.S. Army during World War II
 - George Keyes (1919–2010), American professional golfer
 - Gregory Keyes (born 1963), science fiction and fantasy writer
 - Henry Keyes (1810–1870), American politician and railroad executive
 - Henry W. Keyes (1863–1938), politician
 - Homer Eaton Keyes (1875–1938), Dartmouth professor
 - Hugh T. Keyes (1888–1963), American architect
 - Israel Keyes (1978–2012), American serial killer
 - James W. Keyes, American chief executive, formerly of 7-Eleven and Blockbuster Inc.
 - Jocelyn Marcel Keyes (born 1950), American political activist
 - Joe Keyes (musician) (1907–1950), American jazz trumpeter
 - Johnnie Keyes (1940–2018), early African-American pornographic film actor
 - Josh Keyes (born 1969), American painter and printmaker
 - Ken Keyes (politician) (born 1930), Ontario politician
 - Ken Keyes Jr. (1921–1995), author and lecturer
 - Laurel Elizabeth Keyes (1907-1983), counselor
 - Marcus Keyes (born 1973), American football player
 - Marian Keyes (born 1963), Irish writer
 - Maya Keyes (born 1985), daughter of American politician and diplomat Alan Keyes
 - Michael Keyes (1886–1959), Irish politician
 - Perley Keyes (1774–1834), New York politician
 - Ralph Keyes (born 1961), rugby player
 - Ralph Keyes (author) (born 1945)
 - Sir Robert Keyes (1190-1221), 1216, Knights Templar who fought in the fifth crusade
 - Roger Keyes, 1st Baron Keyes (1872–1945), British admiral and hero
 - Roswell K. Colcord (1839–1939), Governor of Nevada from 1891 to 1895
 - Sidney Keyes (1922–1943), English poet and soldier during World War II
 - Stan Keyes (born 1953), Canadian politician
 - BoPete Keyes (born 1997), American football player
 - Thomas Keyes (1523–1571), Royal gatekeeper to Queen Elizabeth I of England
 - Wade Keyes (1821–1879), Confederate politician
 
See also
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