John Macdonald or MacDonald may refer to:
Government
Australia
- John MacDonald (Australian politician) (1880–1937), Australian senator for Queensland
 
Britain
- John MacDonald II or John of Islay, Earl of Ross (1434–1503), last Lord of the Isles, Scotland
 - John Macdonald, Lord Kingsburgh (1836–1919), Scottish politician and later a judge
 - John Macdonald (British politician, born 1854) (1854–1939), British Liberal politician
 
Canada
- John Small MacDonald (c. 1791–1849), Prince Edward Island merchant and politician
 - John Sandfield Macdonald (1812–1872), first Premier of Ontario
 - John A. Macdonald (1815–1891), first Canadian prime minister
 - John Macdonald (Canadian politician) (1824–1890), member of parliament and later senator
 - John MacDonald of Glenaladale (1742–1810), Scottish born soldier and Prince Edward Island landowner
 - John Alexander MacDonald (Prince Edward Island politician) (1838–1905), speaker of the Prince Edward Island assembly
 - John Alexander Macdonald (Prince Edward Island politician) (1874–1948), member of parliament for King's, Prince Edward Island
 - John Alexander Macdonald Armstrong (1877–1926), politician, conveyancer and real estate agent in Ontario
 - John Alexander Macdonald (Nova Scotia politician) (1883–1945), politician in Nova Scotia
 - John Joseph MacDonald (1891–1986), senator for Prince Edward Island
 - John Michael Macdonald (1906–1997), senator for Nova Scotia
 - John Augustine Macdonald (1913–1961), member of parliament for King's, Prince Edward Island
 - John W. MacDonald (1900–1983), Canadian politician in the Nova Scotia House of Assembly
 - John A. MacDonald (Nova Scotia politician), politician in Nova Scotia
 
United States
- John L. MacDonald (1838–1903), American representative from Minnesota
 - John R. MacDonald (1857–1946), Michigan politician
 
Literature
- John D. MacDonald (1916–1986), American mystery author
 - John McDonald, pseudonym of Kenneth Miller (1915–1983), Canadian-American mystery author, better known as Ross Macdonald
 
Military
- John MacDonald of Garth (1771–1866), Scottish-Canadian participant in the Pemmican war
 - John Macdonald (British Army officer, died 1850) (bef. 1795–1850), Adjutant-General to the Forces
 - John Macdonald (British Army officer, born 1907) (1907–1979)
 - John Macdonald (Australian Army officer) (1919–1996), University of New South Wales Regiment
 - John Denis Macdonald (1826–1908), English naval surgeon and naturalist
 
Music
- John MacDonald (Canadian musician) (born 1948), Canadian–French horn player
 - John-Angus MacDonald (active since 1997), Canadian musician and guitarist
 - John Scantlebury Macdonald, real name of Harry Macdonough (1871–1931), Canadian singer and music recording pioneer
 - John MacDonald of Inverness (1865–1953), Scottish bagpiper
 
Religion
- John MacDonald (bishop of Aberdeen) (1818–1889), Scottish Roman Catholic bishop
 - John MacDonald (Gaelic Moderator) (1779–1849), Scottish minister of the Free Church of Scotland, known as the "Apostle of the North"
 - John MacDonald (vicar apostolic) (1727–1779), Scottish Roman Catholic bishop
 - John Hugh MacDonald (1881–1965), Canadian Roman Catholic prelate, Archbishop of Edmonton
 - John Roderick MacDonald (1891–1959), Canadian Roman Catholic prelate, Bishop of Peterborough, Ontario
 
Sports
- John Macdonald (sportsman) (1861–1938), represented Scotland at both cricket and football
 - John MacDonald (American football) (1885–1962), American football head coach for Boston University
 - John MacDonald (canoeist) (born 1965), New Zealand Olympic canoer
 - John MacDonald (footballer, born 1883) (1883–1915), Scottish footballer for Blackburn Rovers, Leeds City, Grimsby Town
 - John Macdonald (footballer, born 1886) (1886–1960), Scottish footballer for Raith Rovers, Rangers, Liverpool, Newcastle United
 - John MacDonald (footballer, born 1961), Scottish footballer for Rangers, Barnsley
 - John MacDonald (ice hockey), Canadian ice hockey player who played for Destil Trappers in the Netherlands
 - John MacDonald (racing driver) (born 1936), race car driver and motorcycle racer of Hong Kong
 - Jack Macdonald (sportsman) (1907–1982), New Zealand Olympic rower
 - John Macdonald (Canadian football) (born 1978), Canadian football defensive linemen
 - John MacDonald (rugby union, born 1960), Irish rugby union international player
 - John MacDonald (rugby union, born 1890) (1890–1980), Scottish rugby union player
 - John MacDonald (rugby union, born 1938), Scottish rugby union player
 
Other uses
- John Cathanach MacDonald, 4th of Dunnyveg (died 1499)
 - John Macdonald (psychiatrist) (1920–2007), New Zealand forensic psychiatrist who coined the MacDonald triad of sociopathy
 - John S. MacDonald, co-founder of MacDonald Dettwiler
 - John Smyth Macdonald (1867–1941), British physiologist
 - John Graham MacDonald (1834–1918), explorer and pioneer in Queensland, Australia
 - John B. Macdonald (1918–2014), president of the University of British Columbia
 
See also
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