James MacDonald or Macdonald may refer to:
People
Arts and entertainment
- J. E. H. MacDonald (1873–1932), Canadian painter, member of the Group of Seven
- James Stuart MacDonald (1878–1952), art critic and Director of the Art Gallery of NSW
- Jimmy MacDonald (sound effects artist) (1906–1991), voice of Mickey Mouse
- James D. Macdonald (born 1954), American author and critic
- James MacDonald (actor), Canadian actor
- James Macdonald (director) (born 1958), British theater and film director
- James Wilson Alexander MacDonald, American sculptor
Politics
- Sir James Macdonald, 2nd Baronet (1784–1832), British Member of Parliament for Tain Burghs, Newcastle-under-Lyme, Sutherland, Calne, and Hampshire
- James William MacDonald (1811–1881), politician in colonial South Australia and Colonial Treasurer
- James E. MacDonald (1842–1903), former politician in Prince Edward Island, Canada
- James MacDonald (trade unionist) (1857–1938), Secretary of the London Trades Council
- James Alexander MacDonald (1858–1919), lawyer, judge and leader of the British Columbia Liberal Party
- James Ramsay MacDonald (1866–1937), British Prime Minister
- Jim MacDonald (politician) (1917–1989), Australian politician
- James David Macdonald (politician) (1922–1995), City of Calgary alderman and author of Grand Cayman's tax haven law
- James H. MacDonald (1832–1889), lieutenant governor of Michigan
Sports
- James MacDonald (cricketer) (1906–1969), Irish cricketer
- James Macdonald (footballer), Scottish footballer
- Kilby MacDonald (James Allan Macdonald, 1913–1986), Canadian ice hockey player
- Jamie MacDonald (footballer) (born 1986), Scottish football goalkeeper
Other
- James MacDonald, 6th of Dunnyveg (died 1565), Scoto-Irish chieftain
- Sir James MacDonald, 9th of Dunnyveg (died 1626), last chief of Clan MacDonald of Dunnyveg or Clan Donald South
- James Macdonald (British Army officer) (1862–1927), Scottish engineer, explorer and cartographer
- James A. Macdonald (1862–1923), newspaper editor, educator, minister and author in Ontario, Canada
- James Alexander MacDonald (botanist) (1908–1997), Scottish botanist and plant pathologist
- James Macdonald (ornithologist) (1908–2002), British and Australian ornithologist and ornithological writer
- James E. McDonald (1920–1971), American meteorologist and UFO researcher
- James Ross MacDonald (born 1923), American physicist
- James MacDonald (pastor) (born 1960), disqualified pastor of Harvest Bible Chapel, Walk in the Word and Harvest Bible Fellowship
- Sir James Mor Macdonald, 2nd Baronet, Scottish nobleman and soldier
- James MacDonald (police officer) (1968–1993), murdered American police officer
- James Macdonald (civil servant) (1898–1963), British civil servant and forester
Fictional characters
- James MacDonald (Arthur character), a minor character in the TV series Arthur
See also
- Jamie McDonald (disambiguation), including Jamie MacDonald
- James McDonald (disambiguation)
- James Macdonnell (disambiguation)
- Jimmy MacDonald, main character of the television mockumentary series Jimmy MacDonald's Canada
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