Iota (Ι, ι) is the ninth letter of the Greek alphabet.
Iota or IOTA may also refer to:
- Ɩ or Latin iota, a letter of the Latin alphabet
 - Iota (Cyrillic) (Ꙇ, ꙇ), a letter of the Cyrillic alphabet
 
Science and technology
- Infrared Optical Telescope Array
 - Integrable Optics Test Accelerator — electron and proton low energy storage ring and test facility at Fermilab
 - Iota toxin, a type of pore-forming toxin that acts to destroy the actin cytoskeleton.
 - International Occultation Timing Association
 - SARS-CoV-2 Iota variant, a variant of SARS-CoV-2, the virus that causes COVID-19
 
Mathematics
- Denoted by i, the Imaginary unit in the complex number system.
 
Computing
ιn, a function generating a vector of every integer from 0 ton-1 (index origin zero) in APL- Iota and Jot, two esoteric programming languages
 - IOTA (technology), open-source distributed ledger (directed acyclic graph or DAG, a blockchain alternative)
 
Organizations
- International Ovarian Tumor Analysis trial and group, founded to develop standardized terminology
 - Intra-European Organisation of Tax Administrations
 
Arts and entertainment
- Iota, a superhero in the comic book Heroes
 - Colony Iota, a location in Xenoblade Chronicles 3
 - Iota (singer), Australian singer and actor, born Sean Hape
 - Iota, a syndicated newspaper comic strip by Mike Keefe and Tim Menees
 - Iota, 2022 album by Lous and the Yakuza
 
Other uses
- Iota, Louisiana, a town in the US
 - Iota (Italian ship), a vessel from the port of Naples, wrecked in December 1893
 - Islands on the air (IOTA), a list of islands maintained by the Radio Society of Great Britain
 - Hurricane Iota, a late-season Category 4 Atlantic hurricane in 2020
 
See also
- Iota-carrageenan, a type of gelling carrageenan used in the food industry
 - Iota-carrageenase, an enzyme
 - Jota (disambiguation)
 
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