In silico is an expression meaning "performed on computer or via computer simulation".
In silico may also refer to:
- In Silico (Deepsky album), 2002
 - In Silico (Pendulum album), 2008
 
See also
- Insilico Medicine, a biotechnology company
 - In silico medicine
 - In silico clinical trials
 - In silico PCR
 - Insilicos, a software company
 
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