IRM may refer to:
- IERS Reference Meridian
 - Illinois Railway Museum
 - Illinois Reserve Militia, state defense force active during World War II
 - Bureau of Information Resource Management, responsible for information technology of the U.S. Department of State
 - Information Rights Management
 - L'Institut Royal Météorologique de Belgique
 - Interference reflection microscopy, a microscopy method used to image adherent cells
 - Internal Revenue Manual, an official compendium of internal guidelines for personnel of the United States Internal Revenue Service
 - International Review of Mission, a quarterly academic journal
 - International Roaming MIN assigned by IFAST
 - IRM (album), by Charlotte Gainsbourg
 - Iron Mountain Incorporated, a data storage company based in Boston, Massachusetts
 - ICAO designator for Mahan Air, an Iranian airline
 - Islamic Republic of Mauritania
 
See also
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