Geffen (Hebrew: גֶּפֶן, lit. Grapevine) is a Hebrew surname. Notable people with the surname include:
- Aviv Geffen (born 1973), Israeli rock singer
 - David Geffen (born 1943), American record executive, film producer and theatrical producer
 - Jeremy Geffen (1977–2018), American entrepreneur and entertainment executive
 - Maxwell M. Geffen (1896–1980), American editor and publisher from New York
 - Shira Geffen (born 1971), Israeli actress, screenwriter and film director
 - Tobias Geffen (1870–1970), American rabbi from Atlanta, Georgia
 - Yehonatan Geffen (1947–2023), Israeli writer
 
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