Frame is a surname. Notable people with the surname include:
- Billy Frame (1912–1992), Scottish footballer
 - Esther G. Frame (1840–1920), American Quaker minister and evangelist
 - Fred Frame (1894–1962), American race car driver
 - Janet Frame (1924–2004), New Zealand writer
 - John Frame (disambiguation), several people
 - Linley Frame (born 1971), Australian swimmer
 - Margaret Frame (1903–1985), Canadian painter
 - Margaret Frame (biologist), Scottish scientist
 - Pete Frame (born 1942), English music journalist
 - Peter Frame (1957–2018), American ballet dancer
 - Roddy Frame (born 1964), Scottish singer-songwriter and musician (Aztec Camera)
 - Tom Frame (1931–2006), British comic letterer
 - Tom Frame (born 1962), Australian Anglican Bishop
 - William Frame (1848–1906), English architect
 - William Frame (cricketer) (1932–1965), New Zealand cricketer and murder-suicide perpetrator
 - Willie Frame (fl. 1920s), Scottish footballer for Clyde, Motherwell and Linfield
 - Willie Frame (curler), Scottish curler, European champion
 
Fictional characters
- Alice Frame and Steve Frame, on the soap opera Another World
 
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